LightUp® probes in clinical diagnostics
Identifieur interne : 003E32 ( Main/Exploration ); précédent : 003E31; suivant : 003E33LightUp® probes in clinical diagnostics
Auteurs : Mikael Leijon [Suède] ; Mehrdad Mousavi-Jazi [Suède] ; Mikael Kubista [Suède]Source :
- Molecular Aspects of Medicine [ 0098-2997 ] ; 2006.
Descripteurs français
- KwdFr :
- MESH :
- diagnostic : Lymphomes, Syndrome respiratoire aigu sévère.
- génétique : Virus du SRAS.
- immunologie : Lymphomes.
- Charge virale, Humains, Sondes d'ADN, Techniques de diagnostic moléculaire, Techniques de sonde moléculaire.
English descriptors
- KwdEn :
- MESH :
- chemical : DNA Probes.
- diagnosis : Lymphoma, Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- immunology : Lymphoma.
- Humans, Molecular Diagnostic Techniques, Molecular Probe Techniques, Viral Load.
Abstract
The LightUp® Probe technology has now matured and reached the phase where it has been implemented in commercial reagent kits, i.e. the ReSSQ® product line. Several properties of the LightUp® probes make them particularly suitable for clinical settings. For instance, extraordinary shelf life and a chemical stability that allows convenient fridge storage. The origin of the higher stability of LightUp® probe kits compared to others, based on alternative probe technologies, is partly the relatively good stability of cyanine dyes but also the resistance towards nucleases and proteases of the synthetic DNA analogue peptide nucleic acid that is used as the sequence recognizing element in LightUp probes. It is clear from recent trends in the PCR amplification hardware technology that the instrumentation is becoming more flexible and less adapted for dedicated probe chemistries. This will pave the way for increased standardization in the field of DNA diagnostics and the development of cross-platform assays.
In the present review the LightUp technology will briefly be presented and discussed. The utility of the technology will be illustrated by examples from cytomegalovirus quantification and monitoring of the viral load of the SARS Coronavirus. An example of cancer diagnostics by detection of altered gene expression patterns will also be shown.
Url:
DOI: 10.1016/j.mam.2005.12.005
PubMed: 16466783
PubMed Central: 7112358
Affiliations:
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sortKey="Mousavi Jazi, Mehrdad" sort="Mousavi Jazi, Mehrdad" uniqKey="Mousavi Jazi M" first="Mehrdad" last="Mousavi-Jazi">Mehrdad Mousavi-Jazi</name><affiliation wicri:level="1"><nlm:aff id="aff1">LightUp Technologies AB, Lunastigen 5, SE-141 44 Huddinge, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>LightUp Technologies AB, Lunastigen 5, SE-141 44 Huddinge</wicri:regionArea><wicri:noRegion>SE-141 44 Huddinge</wicri:noRegion></affiliation></author><author><name sortKey="Kubista, Mikael" sort="Kubista, Mikael" uniqKey="Kubista M" first="Mikael" last="Kubista">Mikael Kubista</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Chemistry and Biosciences, Molecular Biotechnology, Chalmers University of Technology and TATAA Biocenter, Lundberg Laboratory, 40530 Göteborg, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Chemistry and Biosciences, Molecular Biotechnology, Chalmers University of Technology and TATAA Biocenter, Lundberg Laboratory, 40530 Göteborg</wicri:regionArea><wicri:noRegion>40530 Göteborg</wicri:noRegion></affiliation></author></analytic><series><title level="j">Molecular Aspects of Medicine</title><idno type="ISSN">0098-2997</idno><idno type="eISSN">1872-9452</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>DNA Probes</term><term>Humans</term><term>Lymphoma (diagnosis)</term><term>Lymphoma (immunology)</term><term>Molecular Diagnostic Techniques</term><term>Molecular Probe Techniques</term><term>SARS Virus (genetics)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Viral Load</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Charge virale</term><term>Humains</term><term>Lymphomes (diagnostic)</term><term>Lymphomes (immunologie)</term><term>Sondes d'ADN</term><term>Syndrome respiratoire aigu sévère (diagnostic)</term><term>Techniques de diagnostic moléculaire</term><term>Techniques de sonde moléculaire</term><term>Virus du SRAS (génétique)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA Probes</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphoma</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphomes</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphomes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Lymphoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Molecular Diagnostic Techniques</term><term>Molecular Probe Techniques</term><term>Viral Load</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Charge virale</term><term>Humains</term><term>Sondes d'ADN</term><term>Techniques de diagnostic moléculaire</term><term>Techniques de sonde moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The LightUp<sup>®</sup> Probe technology has now matured and reached the phase where it has been implemented in commercial reagent kits, i.e. the ReSSQ<sup>®</sup> product line. Several properties of the LightUp<sup>®</sup> probes make them particularly suitable for clinical settings. For instance, extraordinary shelf life and a chemical stability that allows convenient fridge storage. The origin of the higher stability of LightUp<sup>®</sup> probe kits compared to others, based on alternative probe technologies, is partly the relatively good stability of cyanine dyes but also the resistance towards nucleases and proteases of the synthetic DNA analogue peptide nucleic acid that is used as the sequence recognizing element in LightUp probes. It is clear from recent trends in the PCR amplification hardware technology that the instrumentation is becoming more flexible and less adapted for dedicated probe chemistries. This will pave the way for increased standardization in the field of DNA diagnostics and the development of cross-platform assays.</p><p>In the present review the LightUp technology will briefly be presented and discussed. The utility of the technology will be illustrated by examples from cytomegalovirus quantification and monitoring of the viral load of the SARS Coronavirus. An example of cancer diagnostics by detection of altered gene expression patterns will also be shown.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adler, H" uniqKey="Adler H">H. Adler</name></author><author><name sortKey="Beland, J L" uniqKey="Beland J">J.L. Beland</name></author><author><name sortKey="Del Pan, N C" uniqKey="Del Pan N">N.C. Del-Pan</name></author><author><name sortKey="Kobzik, L" uniqKey="Kobzik L">L. Kobzik</name></author><author><name sortKey="Brewer, J P" uniqKey="Brewer J">J.P. Brewer</name></author><author><name sortKey="Martin, T R" uniqKey="Martin T">T.R. Martin</name></author><author><name sortKey="Rimm, I J" uniqKey="Rimm I">I.J. 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Grillner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Suède</li></country></list><tree><country name="Suède"><noRegion><name sortKey="Leijon, Mikael" sort="Leijon, Mikael" uniqKey="Leijon M" first="Mikael" last="Leijon">Mikael Leijon</name></noRegion><name sortKey="Kubista, Mikael" sort="Kubista, Mikael" uniqKey="Kubista M" first="Mikael" last="Kubista">Mikael Kubista</name><name sortKey="Mousavi Jazi, Mehrdad" sort="Mousavi Jazi, Mehrdad" uniqKey="Mousavi Jazi M" first="Mehrdad" last="Mousavi-Jazi">Mehrdad Mousavi-Jazi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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